Though emigration to Medina had given Muhammad a certain amount of respite, it increased opposition to his cause tenfold. While at Mecca, the malice of the Qoraish found vent in tormenting the Muslims, but now it was bent on the latter's destruction. The Bedouin tribes, who had so far been mere spectators of the Muslims's persecutions were also stirred at the growth of Islam in Medina. The Jews, being at a distance, were also quiet so far, but now that the Muslims were their next door neighbours in Medina, they could not watch the steady growth of Islam without a sting of jealousy and they rose in opposition. Distinct from all these, and of a singular nature, another wave of opposition set in, in the camp, known in the Islamic phraseology as that of the hypocrites. These were the men who had not the pluck to come out into the open. So they joined the faith with an object of undermining it from within. A certain man, Abdullah bin Ubay, was at their head. Before the immigration of Muhammad, both Banu Aws and Khazraj, wearied by their long drawn-out mutual hostility, which had often erupted into fighting and had exacted a heavy toll of life, had decided to put an end to this state of affairs and to set up a form of administration in Medina which should have the support of both tribes and should also be acceptable to the three Jewish tribes. For this purpose, it had been agreed that Abdullah bin Ubay bin Salul, chief of the Khazraj, should be elected king of Medina. This plan had not yet been put into effect when Muhammad was invited to come to Medina. But Muhammad's presence eclipsed his personality, and he dwindled into a nonentity. He was deeply chagrined at the loss of a crown. At the outset, he offered some opposition, but beholding the rapid growth of Islam, he thought hypocrisy would be a best tool of revenge. Thus he put on the mask of Islam, and thenceforward till his last breath, he left no stone unturned to bring Islam into trouble.

Another important task before Muhammad was to determine and clarify the relations between the various tribes and the Muslims in Medina. The Jews were a considerable power in Medina. It appears that they were Arabs by descent, but formed a distinct unit by reason of their adoption of Judaism. They were subdivided into three clans, the Banu Qainuqa, Banu Nazir and Banu Quraiza. The other inhabitants of the town were the Aws and Khazraj, always at war with each other. Of the two chief clans of the Jews, the Quraiza were the allies of the Aws, while Banu Nazir joined the Khazraj. Now it so happened that the major portion of the Khazraj and Aws embraced Islam. So Muhammad concluded a pact with the Jews, known as the 'Covenant of Medina'(mithaq-i-Medina), whose terms were as follow:- Firstly, the Muslims and Jews shall live as one people. Secondly, each one of the parties shall keep to its own faith, and neither shall interfere with that of the other. Thirdly, in the event of a war with a third party, each was bound to come to the assistance of the other, provided the latter were the pary aggrieved and not the aggressors. Fourthly, in the event of an attack on Medina, both shall join hands to defend it. Fifthly, peace, when desirable, shall be made after consultation with each other. Sixthly, Medina shall be regarded as a sacred by both, all bloodshed being forbidden therein. Seventhly, Muhammad shall be the final court of appeal in cases of dispute.
James A. Michener writes in 'Islam: The Misunderstood Religion' (New York, 1955, p. 68) that, 'Muhammad thus became head of the state and the testimony even of his enemies is that he administered wisely. The wisdom he displayed in judging intricate cases became the basis for the religious law that governs Islam today.'

Five months after his arrival in Yathirab (the Jathrippa in Ptolemy and Stephan, or Jathrb in Minaean inscriptions. The old word Yathirab is found only once in the Koran, 33:13), now known as Medina, it was Muhammad's next task to find shelter and livelihood for the men who had accompanied him from Mecca. In their own home-town many of them were prosperous, but now they were all equally destitute. As a preliminary step, Muhammad enjoined the Muslims of Medina, now known as Ansar (the helpers) to adopt as brothers their co-religionists from Mecca, now known as Muhajir(the refugees), to share with them like their own kith and kin whatever they possessed, in prosperity and in want. He thus created in Anas's house a bond of brotherhood, known as 'Fraternization' (muwakhah), comprising forty-five (or according to another authority, seventy-five) pairs between the Ansars and Muhajirs. This was intended to prove that religion was a firmer basis for brotherly community than membership of the same tribe. These mandates thus resulted in a considerable extension of the Muslim community.
So strong, in short, was this new tie that it surpassed even the relationship of two real brothers.

After Muhammad's arrival in Medina, the first thing to be done was to build a cathedral mosque. It was constructed on the plot of two orphans, Sohal and Sohail, whom Abu Ayub Ansari paid the price. The ground of the plot was levelled and a mosque, 54 yards width and 60 yards in length was built over it with unbaked bricks and mud, and was roofed with palm-wood rafters. This mosque became known as the 'Prophet's Mosque' (Masjid-i-Nabwi) was free from all kinds of artificialites and was a monument of simplicity. Its walls were made of mud bricks, the roof supported by trunks of palm-trees and covered over with the leaves and twigs. The floor was strewn with gravel. In the corner of the courtyard, a sort of a platform with a shed was raised to accomodate those having no home or family. Those who lived there were known as the residents of the Suffa or Platform. This was, so to speak, a kind of seminary attached to the mosque, for these people devoted their whole time to the study of religion. Adjoining the mosque were erected two apartments for the household of Muhammad.

It was the 13th year of Muhammad's mission when the clouds had gathered fast. The Meccan chiefs centred in their Council Hall (darun-nadwa), a chamber inside Kaba, to deliberate over what might be done with Muhammad. Stormy was the meeting, for fear had entered their hearts. Imprisonment for life, expulsion from the city, each was debated in turn for Muhammad. They decided then on a final and desperate remedy, namely to murder Muhammad. Murder by one man would have exposed him and his family to the vengeance of blood. The difficulty was at last solved by Abu Jahl, who suggested that a number of courageous men, chosen from different families, should sheathe their swords simultaneously in Muhammad's bosom, in order that the responsibility of the deed might rest upon all, and the relations of Muhammad might consequently be unable to avenge it. The proposal was accepted, and forty youths were selected for the sanguinary deed. As the night advanced, and it was against the Arab sense of chivalry to kill any one within the four walls of his house at night hour. Hence, the assassins posted themselves round the Muhammad's dwelling, and watched all night long, peeping now and then through a hole in the door to make sure that Muhammad still lay on his bed. In order to keep the attention of the assassins fixed upon the bed, Muhammad put his own green coverlet upon Ali, and bade him to lie on his bed; so as to fail the scheme of his enemies, and himself escaped.
Muhammad had guessed exactly what would be the reactions of the Meccans when they found he had gone. He had, therefore, not started for Yathirab with camel. He had gone on foot with Abu Bakr to Mount Thaur, about one hour's walk from Mecca. They reached Mount Thaur while it was still dark and concealed themselves in the innermost recess of a cave in the rocky hillside. A tracking party, following the footprints of the fugitives, reached the mouth of the cave. Abu Bakr, hearing the sound of their footsteps, grieved within himself. It was a critical moment when the sword of the blood-thirsty enemy was hanging on their heads. Muhammad quieted the fears of Abu Bakr with the words: 'Do no be grieved, for surely God is with us.' For full three days, Muhammad remained in the cave.

On the third night, they came out with two camels. Quickly Muhammad mounted and followed by Abu Bakr, rode into the desert night. They took a certain Abdullah bin Uraiqi, a non-Muslim as their guide. In order to avoid the main caravan tracks, they struck a diagonal course northwest toward the Red Sea. For nearly a week the journey continued over the parched, barren, mournful wasteland. No living creatures, not even vultures or snakes, inhabited this wilderness. They first had proceeded parallel to the Red Sea until they reached a place called Usfan. From here they turned a little inland and travelled for some distance along the foot of Mount Amaj. Then they followed a route parallel to the usual route. They went past Qudayda, al-Kharrar, Thanniyya al-Marrah and Liqfa, and crossed the territories of Banu Madlijah and Banu Aslam, where they alighted for a while. Here Muhammad hired a camel to relieve his own which was exhausted by the long non-stop journey. Before they entered Kuba, they passed through such places as al-Araj, Thanniya al-Ghair and the valley of Ri'm. On the seventh morning after the start of the flight, the oasis of Kuba, a few miles from Yathirab, was sighted. This flight of Muhammad from Mecca to Yathirab (Medina) is called the Hijrah and when Muhammad entered Kuba, with it commenced the Islamic era on 1st Muharram (lunar month) of the Hijrah, or on the date corresponding to July 16, 622 C.E. in the Julian calendar. In English this is usually abbreviated in the Latin form AH (Anno Hegirae i.e., 'in the year of the Hijrah'). This Islamic calendar was introduced after 17 years during the caliphate of Umar.

On the other side in Mecca, Ali slept fearlessly whole night on Muhammad's bed. R.V.C. Bodely writes in 'The Messenger' (London, 1946, p. 113) that, 'The morning breeze whispered over the desert. The dawn came mauvely from the east and showed the assassins braced to strike. As the first white rays of the rising sun hit the flat roofs of Mecca, the door of Muhammad's house opened. The men stood ready to spring. They then held back as their astonished eyes rested on the burly figure of Ali standing on the threshold carrying Muhammad's cloak over his arms.' The assassins at first thought of killing him, but when they found him ready to defend himself, they gave up the idea and dispersed in search of Muhammad. Discomfited and unhappy, they immediately dispatched their best riders in pursuit of the fugitive. Up and down they hunted over all the tracks and passes leading out of Mecca, but found no trace of Muhammad.

Ali stayed three days at Mecca and handed back all the articles which were entrusted to Muhammad for safe custody, mostly by his enemies, secured their receipts and quitted the city in broad daylight. Ali was also assigned for safe transport of Muhammad's daughter Fatima, the daughter of Hamza, another Fatima, his own mother, Fatima bint Asad, and his aunt, that was the daughter of Abdul Mutalib, a fourth Fatima. On account of scarcity of mounts, Ali had to travel on foot, and reached Kuba with bleeding feet. Muhammad embraced him, and dressed his feet. Muhammad stayed with the clan of Umar bin Auf at Kuba for 14 days, and during which time he laid foundation of the first mosque (Arabic masjid, the English mosque through the Italian moschea) of Islam. It is of this mosque that Koran (9:109) speaks as 'the mosque founded on piety.'

The news of Muhammad's arrival at Kuba soon reached Yathirab and the city had been in eager expectation of his arrival. Each morning some people would go out on the outskirts to watch the appearance of their revered master. The tedious hours of impatient expectancy were at last over, and the illustrious visitor appeared on the horizon of Yathirab. At last the great day arrived. News was brought to Yathirab that Muhammad was on his way. He entered the city on September 22, 622. Yathirab was wearing to look of jubilation all round. People came out to greet Muhammad, clad in their gayest attire. Women climbed to the tops of their houses and sang in chorus to welcome their noble guest. Syed Waheeduddin writes in 'The Benefactor' (Lahore, 1964, p. 33) that, 'The Banu Najjar led the welcoming crowds in full armour, their weapons glistening in the sun. The whole of Yathirab lined the road in orderly rows. Young girls played on their tambourines and sang songs of welcome.' There was an unprecedented merry-making, and when Muhammad came to the group of Umar bin Awf Najjari, the well-dressed girls came out of seclusion, danced and sang to the tune of music the following ballad:

Nahno jowarun min bani Najjarin,
Janadan Muhammad min Jarin.
'We belong to the clan of Najjar, (we are) Muhammad's soldiers from the Jari.'

Each tribe, which Muhammad passed through in the city, very eagerly desired the honour of his presence and requested him to take up his abode with them. He, refusing all these offers, said that the camel, which he rode on, was inspired and would take him to the proper quarter. The camel proceeded on to the eastern quarter, and knelt down in the open courtyard of the Banu Najjar, near the house of Abu Ayub Ansari. He took up his temporary residence in his house for about seven months, until a mosque with proper quarters for himself was built in Medina.

A ray of hope beamed in the interim in the north. At a distance of about 250 miles from Mecca was a town then known as Yathirab, and later as Medina. Its population was divided into two groups, the Jews and pagans. The pagans had two clans, Aws and Khazraj, who were generally at loggerheads with each other. Every year in the month of Rajab, the Arabs swarmed like locusts into Mecca. One day in Mecca, whilst sadly but yet hopefully working among the half-traders and half-pilgrims, Muhammad came upon a group of six men who were of Khazraj. Meeting them perchance, Muhammad led them to a declivity and recited to them the verses from Koran, enumerated the blessings of a good and pious life and beckoned them to the fold. Struck by his earnestness and the truth of his words, they embraced Islam. When they returned to their native Yathirab, they spread the news, with lightning rapidity that a Prophet had arisen among the Arabs in Mecca. The town was soon agog with stories of the new faith and its wonderful leader. So the ensuing year another twelve pilgrims came to Mecca and made their vows at the same spot which had witnessed the conversion of the former six. This is called the first pledge of Aqaba, from the name of the hill on which the conference was held. The following year, 622 A.D., the Yathirabites who had adopted the new religion repaired to Mecca. In the stillness of night, when all inimical elements appeared slumbering, these seventy-two pioneers of the new faith met under the same hill. Muhammad appeared among them, and vividly described to them the risk they incurred by adopting Islam. They replied with one voice that they adopted the religion fully conscious of the dangers that surrounding them. Thus was concluded the second pledge of Aqaba.

On his return to Mecca during the night, Muhammad arrived at Nakhlah, and thence he moved to Hira. According to Ibn Sa'd (1st vol., p. 212), Muhammad sent words to Mutim bin Adi that he desired to return to Mecca, if he was assured protection. Mutim, although a non-believer, was a gentleman. He not only assured Muhammad of his protection according to Arabian custom, but called all of his sons who went to Kaba and remained on guard till he finished his religious obligations. Mutim also declared in Mecca that Muhammad was under his protection.
He was sorely stricken in heart and lived in Mecca for some time, retired from his people, preaching occasionally, but confining his mission mainly to the strangers who congregated in Mecca and its vicinity during the season of the annual pilgrimage

Weighed down by the loss of his venerable protector and of his cherished wife, Muhammad determined to turn to some other field for the exercise of his ministry, because the Meccans had rejected the words of God. Taif was about 75 miles south-east of Mecca, and a famous home of Banu Thaqif. Accompanied by Zaid, he arrived in Taif, and invited at first the three brothers of Umayr family to adore One God. His words caused a storm of indignation and his voice was drowned by clamours. He was wounded by stones thrown at him, and which the faithful Zaid endeavoured in vain to ward off. They incited to ruffians of the town to ridicule him. The ruffians drove him from the town, and the rabble and the slaves too followed, hooting, reviling and pelting him with stones for a distance of three miles, until the evening, when they quitted Muhammad to pursue his way alone. Blood flowed from his both legs. He, wearied and mortified, took refuge in one of the numerous orchards, and rested under a vine.

It was during this period that al-Isra and al-Miraj had taken place. Al-Asra means the night journey when Muhammad was reported to have taken from Mecca to the Mosque of Aqsa, the distance mosque of Jerusalem. Al-Miraj means Muhammad's ascension to heaven and his visit to paradise and hell. On the night of al-Isra, Muhammad was staying in the house of his cousin, Hind, daughter of Abu Talib, who was also called Umm Hani. Hind relates that the Prophet of God spent the night in my quarters. He recited the night prayers and went to sleep. Just before dawn, the Prophet of God awoke us and we all prayed the dawn prayer together. When the prayer was through, he said, 'O Umm Hani, I prayed with you the night prayer in this place; then I went to Jerusalem and I prayed there, and as you see, I have just finished praying with you the dawn prayer.' I answered, 'O Prophet of God! do not tell this to the people, for they will belie you and harm you.' He said, 'By God, I shall tell them.'
Those who claim that al-Isra and al-Miraj of Muhammad had taken place spiritually rather than physically, have based their arguments on the aforesaid report of Umm Hani. They also refer to another report of Aisha which says, 'The body of the Prophet of God was never missed from his bed. Rather, God caused him to travel in soul alone.' Whenever Muawiya bin Abu Sufian was asked about it, he used to answer, 'It was a true vision from God.' Those who share such a view confirm their claim with the Koranic verse, 'The vision which We have shown you is but a trial to the people' (17:60). According to the other view, al-Isra from Mecca to Jerusalem took place in body. In confirmation of this, they mention that Muhammad had related what he saw in the desert on the way hither and add that his ascension to heaven was in soul. Other hold that both al-Isra and al-Miraj were in body. As a result of this great divergence of opinion, thousands of volumes have been written on the subject.

If we may have a cursory glance on the biography of Abu Talib, we will find that he supported Muhammad for full 40 years, and displayed sacrifice during last ten years of his life. The only factor which kept him so steadfast was his strong faith, which he had to keep secret in Mecca, exercising strict taqiya (precautionary dissimulation). According to 'Sirat-i Halabiya' (1st vol., p. 390), Abu Talib said to his children at the time of his death that, 'I recommend Muhammad to you, because he is the trusted one of Qoraish and truthful one of Arabia and possesses all the virtues. He has brought a religion, which has been accepted by the hearts, but the tongues have chosen to deny it on account of fear of taunts. Whosever follows him becomes prosperous of his faith. If death had given me some more time, I would have warded off all the dangers that came to him.'
Imam Jafar Sadik, according to 'Usul-i Kafi' (p. 244) had said: 'Abu Talib was like the People of the Cave, who had faith in their hearts but pretended to be polytheists.' In one laudatory poem about his nephew, Abu Talib had said, as quoted by 'Majma'ul Bayan' (7th vol., p. 36) that, 'Dont you know that we consider Muhammad to be a Prophet of Allah like Musa bin Imran and read about him in the earliest book.' In sum, it is quite true that Abu Talib had never publicly announced to embrace Islam, and this is the principal cause that the historians have doubted his faith. When a mention was made about Abu Talib, Imam Zayn al-Abidin is reported to have said, 'I wonder why people doubt the faith of Abu Talib, when a woman cannot continue her matrimonial alliance with a non-Muslim husband after she has embraced Islam, and Fatima bint Asad was amongst those women who embraced Islam at a very early stage and still remained his wife till he breathed his last.'